abstract：:The quantitation of Lp(a) by immunoassay presents a major technical problem, because the molecular mass of the (a) protein of Lp(a) can vary between 419,000 and 838,000 Da (Gaubatz et al. (1990) J. Lipid Res. 31, 603-612), and this variability is determined by at least 24 alleles of the (a) gene. In an attempt to over...

journal_title：Chemistry and physics of lipids

authors： Kottke BA,Bren ND

更新日期：1994-01-01 00:00:00

abstract：:The extracorporeal procedure for the specific removal of lipoprotein (a) (Lp(a)) from human plasma--Lp(a) apheresis--was applied to the treatment of three patients with coronary artery disease documented by angiography. Their initial lipid levels were as follows: total cholesterol, 210-230 mg/dl; low-density lipoprote...

journal_title：Chemistry and physics of lipids

authors： Pokrovsky SN,Sussekov AV,Afanasieva OI,Adamova IY,Lyakishev AA,Kukharchuk VV

更新日期：1994-01-01 00:00:00

abstract：:To investigate the efficacy of reducing plasma lipoprotein(a) (Lp(a)) as well as low density lipoprotein cholesterol (LDL-C) levels on the prevention of restenosis after PTCA, LDL-apheresis was attempted on a total of 54 patients at six institutions. LDL-apheresis using a dextran sulfate cellulose column has been prov...

journal_title：Chemistry and physics of lipids

authors： Yamaguchi H,Lee YJ,Daida H,Yokoi H,Miyano H,Kanoh T,Ishiwata S,Kato K,Nishikawa H,Takatsu F

更新日期：1994-01-01 00:00:00

abstract：:Apolipoprotein B-100 (apoB-100) is the major protein in low-density lipoprotein (LDL) and contains the ligand for binding LDL to its cell surface receptor. Lipoprotein [a] (Lp[a]) is a lipoprotein that consists of LDL and apolipoprotein [a] (apo[a]). The primary structure of apoB-100 has been determined by a combinati...

journal_title：Chemistry and physics of lipids

authors： Yang C,Gu ZW,Yang M,Gotto AM Jr

更新日期：1994-01-01 00:00:00

abstract：:Lipoic acid-substituted phospholipids were synthesized from phosphatidyl cholines by exchanging the choline residue with a glycol group using phospholipase D, forming phosphatidylglycols, and coupling of lipoic acid (1,2-dithiolane-3-pentanoic acid) to the residual glycol hydroxyl group by esterification. The thermotr...

journal_title：Chemistry and physics of lipids

authors： Pax H,Blume A

更新日期：1993-11-01 00:00:00

abstract：:Divalent cation (Ca2+ and Mg2+) and hydrogen ion-induced fusions of small unilamellar phosphatidic acid vesicles were studied by the use of fluorescence fusion assay. These fusogenic ions also increased interfacial tension and reduced the surface dielectric constant of phosphatidic acid membranes as the ion concentrat...

journal_title：Chemistry and physics of lipids

authors： Ohki S,Zschörnig O

更新日期：1993-10-01 00:00:00

abstract：:This minireview describes the use of fluorescence polarization to characterize the dynamics and organization of biological membranes, lipoproteins, liposomes and other lipid-based assemblies. The advantages, disadvantages and limitations of this method are discussed. There is special emphasis on the multiprobe approac...

journal_title：Chemistry and physics of lipids

authors： Borenstain V,Barenholz Y

更新日期：1993-09-01 00:00:00

abstract：:In the first part of this article, chemical and physical stability of aqueous liposome dispersions have been addressed. Chemical stability of phospholipids has been considered in two parts: oxidation and hydrolysis. Major attention has been paid to hydrolysis kinetics of phospholipids as a function of pH, temperature,...

journal_title：Chemistry and physics of lipids

authors： Grit M,Crommelin DJ

更新日期：1993-09-01 00:00:00

abstract：:Aqueous dispersions of 1,2-bis(10,12-tricosadiynoyl)-sn-glycero-3-phosphocholine, on cooling below the chain melting temperature, form hollow cylindrical structures known as 'tubules'. We have studied the formation of tubules in methanol/water, ethanol/water and n-propanol/water. For each alcohol, there is a defined w...

journal_title：Chemistry and physics of lipids

authors： Ratna BR,Baral-Tosh S,Kahn B,Schnur JM,Rudolph AS

更新日期：1992-11-01 00:00:00

abstract：:Low density lipoprotein (LDL) cholesterol is known to be oxidized both in vitro and in vivo giving rise to oxygenated sterols. Conflicting results, however, have been reported concerning both the nature and the relative concentrations of these compounds in oxidized human LDL. We examined the extracts obtained from Cu(...

journal_title：Chemistry and physics of lipids

authors： Malavasi B,Rasetti MF,Roma P,Fogliatto R,Allevi P,Catapano AL,Galli G

更新日期：1992-10-01 00:00:00

abstract：:The role of the ceramide moiety of gangliosides, together with the deriving aggregative properties of ganglioside in solution, in the process of ganglioside-cell interactions was studied. The natural GM1(stearoyl) and the synthetic GM1(acetyl), containing the stearoyl and acetyl groups as the acyl moiety, respectively...

journal_title：Chemistry and physics of lipids

authors： Bassi R,Sonnino S

更新日期：1992-07-01 00:00:00

abstract：:Three novel polymerizable ether lipids, 1,2-O-bis[10(2',4'-hexadienoyloxy)decyl]-rac, 1,2-O-bis(10,12-tricosadiynyl)-rac, and (-)-2,3-O-bis(10,12-tricosadiynyl)-sn-glycero-1-phosphocholine, were synthesized from 3-O-benzyl-rac, 3-O-trityl-rac and (-)-1-O-trityl-sn-glycerol as starting materials, respectively. All the ...

journal_title：Chemistry and physics of lipids

authors： Lee YS,O'Brien DF

更新日期：1992-05-01 00:00:00

abstract：:The indolic plant hormone, indole-3-acetic acid (IAA), mediated the transport of Mn2+ and other ions into small unilamellar vesicles prepared from soybean phosphatidylinositol (PI) and this process has been studied using 31P nuclear magnetic resonance spectroscopy (NMR). The rate of Mn2+ movement into PI vesicles is d...

journal_title：Chemistry and physics of lipids

authors： Jones GP,Misso NL,Paleg LG

更新日期：1992-04-01 00:00:00

abstract：:The effect of several synthetic peptides based on the sequence of human pulmonary surfactant-associated protein B (SPB) on the molecular packing of model membrane lipids (7:1 dipalmitoyl phosphatidylcholine (DPPC)/dipalmitoyl phosphatidylglycerol (DPPG)) was studied using fluorescence anisotropy. This information was ...

journal_title：Chemistry and physics of lipids

authors： Baatz JE,Sarin V,Absolom DR,Baxter C,Whitsett JA

更新日期：1991-12-01 00:00:00

abstract：:Racemic 1-O-(2-methyloctadecyl)-2-O-acetyl-glycero-3-phosphocholine, a branched chain PAF species, was prepared by chemical synthesis and investigated for biological activity on human blood platelets in vitro. The synthesis started from 2-O-benzylglycerol and 2-methyloctadecyl-1-methyl sulfonate and was accomplished i...

journal_title：Chemistry and physics of lipids

authors： Schmid B,Ostermann G,Kertscher HP

更新日期：1991-11-01 00:00:00

abstract：:A new scheme for synthesis of saturated 1-O-alkyl-2-O-methyl-rac-glycerolipids is described. The reductive cleavage of 2-O-methyl-1,3-O,O-benzylideneglycerol with BH3.THF complex leads to 1-O-benzyl-2-O-methyl-rac-glycerol, which is a key in intermediate for the facile preparation of 1-O-alkyl-2-O-methyl-rac-glycerol ...

journal_title：Chemistry and physics of lipids

authors： Pinchuk AN,Mitsner BI,Shvets VI

更新日期：1991-10-01 00:00:00

abstract：:Phospholipid vesicles like erythrocyte ghosts [1] have been shown to display trends in freeze-thaw injury with Group I ions which are non-monotonic in nature. That is to say, the relative extent of injury with such ions, measured as calcein release, does not follow a lyotropic series related solely to the hydrated ion...

journal_title：Chemistry and physics of lipids

authors： Brearley CA,Hodges NA,Oliff CJ

更新日期：1991-09-01 00:00:00

abstract：:A fluorescent assay for Clostridium perfringens phospholipase C is described using 1-palmitoyl-2-[6(pyren-1-yl)hexanoyl]-sn-glycero-3- phospho-N-(trinitrophenyl)aminoethanol (PPHTE) as the substrate. This method is based on the decrease of the quenching of pyrene monomer fluorescence when phospholipase C hydrolyzes PP...

journal_title：Chemistry and physics of lipids

authors： Thuren T,Kinnunen PK

更新日期：1991-08-01 00:00:00

abstract：:The effect of peptides on bilayer----non-bilayer phase transitions can be used as a tool to investigate the molecular aspects of peptide-lipid interactions. In this contribution the action on membranes of the peptide antibiotic gramicidin A and the bee venom component melittin are compared. Although the known structur...

journal_title：Chemistry and physics of lipids

authors： Tournois H,de Kruijff B

更新日期：1991-03-01 00:00:00

abstract：:A brief review is given on the principles and methods used to investigate structural phase transitions in phospholipid supramolecular structures. The conceptual differences of approaches close to and far from equilibrium are addressed, and the consequences in terms of the limits of interpretation for different types o...

journal_title：Chemistry and physics of lipids

authors： Laggner P,Kriechbaum M

更新日期：1991-03-01 00:00:00

abstract：:In liotropic lipid systems phase transitions can be induced isothermally by changing the solvent concentration or composition; alternatively, lipid composition can be modified by (bio)chemical means. The probability for isothermal phase transitions increases with the decreasing transition entropy; it is proportional t...

journal_title：Chemistry and physics of lipids

authors： Cevc G

更新日期：1991-03-01 00:00:00

abstract：:Dynamic light scattering has been used to study the temperature dependence of the extent of long-time calcium-induced fusion of sonicated vesicles composed of various natural and synthetic phosphatidylserine with different acyl chains. The vesicles of each composition are found to exhibit a peak temperature in the vic...

journal_title：Chemistry and physics of lipids

authors： Leung SO,Ho JT

更新日期：1991-01-01 00:00:00

abstract：:Fourier transform infrared (FTIR) and time-resolved fluorescence spectroscopy have been employed to examine the structural dynamics of lipid fatty acyl chains and lipid/water interfacial region of a binary lipid mixture containing unsaturated phosphatidylethanolamine (PE) and diacylglycerol (DG). Infrared vibrational ...

journal_title：Chemistry and physics of lipids

authors： Chen SY,Cheng KH

更新日期：1990-12-01 00:00:00

abstract：:Some thermodynamic and structural aspects of propranolol-DPPC liposomes interaction were investigated by DSC and X-ray diffraction: the lamellar arrangement of the lipid matrix remains intact even at high concentrations of the drug (until 1:1 drug/lipid molar ratio). However, the bilayer thickness increases significan...

journal_title：Chemistry and physics of lipids

authors： Albertini G,Donati C,Phadke RS,Ponzi Bossi MG,Rustichelli F

更新日期：1990-09-01 00:00:00

abstract：:In this report we have investigated the differences in the uptake and metabolization of exogenous GM1 by human fibroblasts, as a function of its supramolecular organization in solution. For this we used a tritium labelled GM1, given alone or inserted in dispersions of phosphatidylcholine (PC) or sulphatide. The additi...

journal_title：Chemistry and physics of lipids

authors： Giglioni A,Chigorno V,Pitto M,Valsecchi M,Palestini P,Ghidoni R

更新日期：1990-08-01 00:00:00

abstract：:[4,4-2H2]-, [5,5-2H2)-, [6-2H]-, [7-2H]-, [8,8-2H2)-, [11,11-2H2]-, [14,14-2H2]- and [18,18,18-2H3]-cis,cis-octadeca-6,9-dienoic (isolinoleic) acid were synthesized by supplementing cultures of the protozoan Tetrahymena with the corresponding deuterated cis-octadeca-9-enoic (oleic) acids. The cultures were harvested, ...

journal_title：Chemistry and physics of lipids

authors： Baenziger JE,Smith IC,Hill RJ

更新日期：1990-04-01 00:00:00

abstract：:An investigation into the effect of alpha-tocopherol on phospholipid model membranes has been carried out by electron spin resonance (ESR) and saturation transfer ESR. The use of stearic acid and of perdeutero -di-t-butyl nitroxide spin probes has allowed us to monitor, in particular, the effect of alpha-tocopherol on...

journal_title：Chemistry and physics of lipids

authors： Severcan F,Cannistraro S

更新日期：1990-03-01 00:00:00

abstract：:The aggregative properties of highly pure GM3 ganglioside in aqueous solution have been studied by static and dynamic laser light scattering measurements and fluorescence spectroscopy experiments performed by the use of a GM3 derivative containing the pyrene group at the end of the fatty acid moiety. GM3 ganglioside s...

journal_title：Chemistry and physics of lipids

authors： Sonnino S,Cantu L,Acquotti D,Corti M,Tettamanti G

更新日期：1990-02-01 00:00:00

abstract：:The current-voltage steady-state characteristics, cyclic voltammograms and capacitance-voltage steady-state relationships of bilayer lipid membranes made from dioleoylphosphatidylcholine or its mixtures with dolichyl-12 phosphate have been studied. Sustained fluctuations of the capacitance of dolichyl phosphate modifi...

journal_title：Chemistry and physics of lipids

authors： Janas T,Kuczera J,Chojnacki T

更新日期：1990-01-01 00:00:00

abstract：:A series of polyprenyl phosphates with modified structure of polyprenyl residue was prepared through phosphorylation of polyprenyl trichloroacetimidates with phosphoric acid. Interaction of polyprenols with tetra-n-butylammonium dihydrogen phosphate and trichloroacetonitrile was found to represent a very efficient, si...

journal_title：Chemistry and physics of lipids

authors： Danilov LL,Druzhinina TN,Kalinchuk NA,Maltsev SD,Shibaev VN

更新日期：1989-11-01 00:00:00

abstract：:The orientational order and rotational dynamics of 1-palmitoyl-2-[[2-[4-(6-phenyl-trans-1,3,5- hexatrienyl)phenyl]ethyl] carbon yl]-3-sn-phosphatidylcholine (DPH-PC) in dilinoleoylphosphatidylethanolamine (DLPE) and 1-palmitoyl-2-oleoylphosphatidylcholine (POPC) binary lipid mixtures were investigated. A previous stud...

journal_title：Chemistry and physics of lipids

authors： Cheng KH

更新日期：1989-10-01 00:00:00

abstract：:A fluorescence spectroscopy global data analysis environment is described. Within this analysis environment, multidimensional fluorescence decay data (time and frequency domains) can be analyzed in terms of a wide variety of photophysical models. A generalized compartmental analysis structure is utilized, where one ca...

journal_title：Chemistry and physics of lipids

authors： Beechem JM

更新日期：1989-06-01 00:00:00

abstract：:5 alpha-Cholest-8(14)-en-3 beta-ol-15-one is a potent inhibitor of cholesterol biosynthesis which has significant hypocholesterolemic activity upon oral administration to rodents and nonhuman primates. In the present study the metabolism of the 15-ketosterol has been investigated after the oral administration of a mix...

journal_title：Chemistry and physics of lipids

authors： Pajewski TN,Brabson JS,Kisic A,Wang KS,Hylarides MD,Jackson EM,Schroepfer GJ Jr

更新日期：1989-03-01 00:00:00

abstract：:The gel-like liquid phase transition of dimyristoylphosphatidylcholine (DMPC) large unilamellar vesicles prepared by reverse phase evaporation has been investigated in buffers containing ethanol by quasi-elastic light scattering (QLS) and vibrational (infrared and Raman) spectroscopy. With the QLS technique, the relat...

journal_title：Chemistry and physics of lipids

authors： Hantz E,Cao A,Taillandier E

更新日期：1988-12-01 00:00:00

abstract：:This report presents the first X-ray diffraction data on diacetylenic phospholipids. The tubule-forming polymerizable lipid, 1,2-bis(10,12-tricosadiynoyl)-sn-glycero-3-phosphocholine (DC8,9PC), was studied by low angle X-ray diffraction from partially dehydrated oriented multibilayers in both polymerized and unpolymer...

journal_title：Chemistry and physics of lipids

authors： Rhodes DG,Blechner SL,Yager P,Schoen PE

更新日期：1988-11-01 00:00:00

abstract：:A comparative study of the polymorphism exhibited by the polymerizable, tubule-forming phospholipid 1,2-bis(10,12-tricosadiynoyl)-sn-glycero-3- phosphocholine (DC23PC) and its saturated analog 1,2-ditricosanoyl-sn-glycero-3-phosphocholine (DTPC) in aqueous suspension is reported. Differential scanning calorimetry (DSC...

journal_title：Chemistry and physics of lipids

authors： Burke TG,Rudolph AS,Price RR,Sheridan JP,Dalziel AW,Singh A,Schoen PE

更新日期：1988-10-01 00:00:00

abstract：:The X-ray crystal structure of 3 beta-benzoyloxy-6 alpha-chloro-5 alpha-cholest-7-ene (IV) was determined by the heavy atom method and refined to R = 0.063 (space group P21, a = 11.364, b = 11.089, c = 12.232, beta = 99.43 degrees, Z = 2). IV was previously shown to be an important intermediate in the acid-catalyzed i...

journal_title：Chemistry and physics of lipids

authors： Wilson DK,Wilson WK,Quiocho FA,Schroepfer GJ Jr

更新日期：1988-08-01 00:00:00

abstract：:We consider the situation of integral membrane proteins in a lipid bilayer matrix where the size of the polar group of the protein is important in determining the lateral packing of the proteins. We represent the cross-section of the protein hydrophobic core as a hexagon moving on a lattice, and represent the projecti...

journal_title：Chemistry and physics of lipids

authors： Pink DA,Chisholm DM,Chapman D

更新日期：1988-04-01 00:00:00

abstract：:Small unilamellar vesicles (SUV) formed by egg yolk phosphatidylcholine (PC) and free oleic acid (OA) undergo aggregation induced by Ca2+ at pH greater than 7.0. The rate of the process, as monitored by turbidity changes, presents a linear dependence on phospholipid concentration and a hyperbolic dependence on Ca2+ co...

journal_title：Chemistry and physics of lipids

authors： Ortiz A,Gomez-Fernandez JC

更新日期：1988-04-01 00:00:00

abstract：:Reported herein is the synthesis of (+)- and (-)-(1,3/2)-1-O-(phosphocholine)-2,3-O-dihexanoylcyclopentane-1,2, 3-triol. These are the enantiomers of a contrained analogue of dihexanoylphosphatidylcholine in which the glycerol backbone is replaced by all-trans cyclopentane-1,2,3-triol. Evidence is presented to demonst...

journal_title：Chemistry and physics of lipids

authors： Barlow PN,Vidal JC,Lister MD,Hancock AJ,Sigler PB

更新日期：1988-03-01 00:00:00